Mobile Health Application Tracking of Iron Adherence and Hemoglobin Outcomes in Mildly Anemic Adolescent Girls
Abstract
Anemia among adolescent girls remains a significant public health challenge in Indonesia, with prevalence increasing from 37.1% in 2013 to 48.9% in 2018. Despite the implementation of a national iron supplementation program, adherence rates remain critically low, ranging from 1% to 10%. This study investigated the correlation between adherence to iron supplementation and hemoglobin levels in adolescent girls with mild anemia. A total of 76 female students aged 16–18 years, presenting with baseline hemoglobin levels of 11.0–11.9 g/dL, were enrolled from four schools in Jember Regency, East Java. Participants were equally divided into an intervention group receiving the MonEv application and a control group, with a follow-up period of four months. The results demonstrated progressive improvements in the intervention group: the proportion of participants with good knowledge increased from 1.3% to 30.3%, those exhibiting positive attitudes rose from 3.9% to 31.6%, and normal hemoglobin levels were achieved by 42.1% of participants by the fourth month. A statistically significant correlation between adherence to iron supplementation and hemoglobin normalization was observed at four months (p = 0.003), indicating that sustained digital monitoring meaningfully supports biological recovery. These findings demonstrate the potential of mobile health (mHealth) technology as a scalable, evidence-based strategy for adolescent anemia prevention in low-resource settings.
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Alghabiwi, R. S., Yahya, A. A. D., Ahmed, W., Albeshri, A., Albayedh, J. J., Alshammari, A. A., Alkhathami, F. S. A., Alghannam, J. H., & Mariee, A. A. (2025). Nurses Led Interventions to Combat Female Adolescents’ Anemia: A Systematic Review. Vascular and Endovascular Review. https://doi.org/10.64149/J.Ver.8.20s.62-75
Andriastuti, M., Ilmana, G., Nawangwulan, S. A., & Kosasih, K. A. (2020). Prevalence of anemia and iron profile among children and adolescent with low socio-economic status. International Journal of Pediatrics and Adolescent Medicine, 7(2), 88–92. https://doi.org/https://doi.org/10.1016/j.ijpam.2019.11.001
Balcha, W. F., Eteffa, T., Arega Tesfu, A., & Abeje Alemayehu, B. (2023). Maternal Knowledge of Anemia and Adherence to its Prevention Strategies: A Health Facility-Based Cross-Sectional Study Design. Inquiry (United States), 60. https://doi.org/10.1177/00469580231167731
Belay, D. G., Amlak, B. T., Chilot, D., Alem, A. Z., & Merid, M. W. (2025). Pooled prevalence of anaemia and its associated factors among adolescent girls in East and West Africa: a systematic review and meta-analysis. BMC Public Health, 25(1). https://doi.org/10.1186/s12889-025-23701-4
Elsharkawy, N. B., Abdelaziz, E. M., Ouda, M. M., & Oraby, F. A. (2022). Effectiveness of Health Information Package Program on Knowledge and Compliance among Pregnant Women with Anemia: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health, 19(5). https://doi.org/10.3390/ijerph19052724
Fitri, A. A., Rahfiludin, M. Z., & Agushybana, F. (2025). Digital Media Interventions for Anemia Prevention Among Adolescent Girls: A Scoping Review. Media Publikasi Promosi Kesehatan Indonesia (MPPKI), 8(12), 1602–1616. https://doi.org/10.56338/mppki.v8i12.8449
Ghafouri, R., Azizi, Z., Moradi, S., & Nazari, M. (2026). Comparative impact of edutainment education via web application and mobile application on anemia prevention. Scientific Reports, 16(1), 1–9. https://doi.org/10.1038/s41598-025-31024-y
Gosdin, Lucas, Sharma, J, A., Tripp, Katie, Amoaful, Foriwa, Esi, Mahama, B, Abraham, Selenje, Lilian, Jefferds, M. E., Martorell, R., Ramakrishnan, U., & Addo, O. Y. (2021). A School-Based Weekly Iron and Folic Acid Supplementation Program Effectively Reduces Anemia in a Prospective Cohort of Ghanaian Adolescent Girls. Journal of Nutrition, 151(6), 1646–1655. https://doi.org/10.1093/jn/nxab024
Handayani, Y., Winarso, S., Ningtyias, W., & Farida. (2021). The Effectiveness Of Android Based Applications An Adherence Monitoring System For Adolescent Female Consumption Fe Tablets. Journal of Dr Soebandi Health, 9(2), 115–124. https://doi.org/10.36858/jkds.v9i2.293
Handiso, Y. H., Belachew, T., Abuye, C., Workicho, A., & Baye, K. (2021). A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia. Scientific Reports, 11(1), 1–7. https://doi.org/10.1038/s41598-021-89115-5
Helmyati, S., Syarifa, C. A., Rizana, N. A., Sitorus, N. L., & Pratiwi, D. (2023). Acceptance of Iron Supplementation Program among Adolescent Girls in Indonesia: A Literature Review. Amerta Nutrition, 7(3SP), 50–61. https://doi.org/10.20473/amnt.v7i3SP.2023.50-61
Hong, S. H., Chun, T. K., Nam, Y. J., Kim, T. W., Cho, Y. H., Son, S. J., Roh, H. W., & Hong, C. H. (2025). Digital Mental Health Interventions for Adolescents: An Integrative Review Based on the Behavior Change Approach. Children, 12(6), 770. https://doi.org/10.3390/children12060770
Kementerian Kesehatan RI. (2023). Profil Kesehatan Indonesia Tahun 2022. Jakarta: Kementerian Kesehatan Republik Indonesia.
Laurence, M. C., Titaley, C. R., Tahitu, R., Asmin, E., Kailola, N. E., Istia, S. S., Tando, Y. D., Pasamba, L. A., & Sara, L. S. (2025). The effect of WhatsApp-based reminders on enhancing knowledge and adherence to weekly iron-folic acid supplementation among adolescent girls in Maluku, Indonesia. Frontiers in Digital Health, 7(March), 1–10. https://doi.org/10.3389/fdgth.2025.1542006
Rahmatina, A. N., Ghozali, M., Adnani, Q. E. S., Hilmanto, D., Zuhairini, Y., Susiarno, H., & Panigoro, R. (2025). A Scoping Review of Nutritional Intake and Physical Activity in Adolescent Girls with Anemia. International Journal of Women’s Health, 17, 2891–2907. https://doi.org/10.2147/IJWH.S519269
Sari, P., Herawati, D. M. D., Dhamayanti, M., & Hilmanto, D. (2022). Anemia among Adolescent Girls in West Java, Indonesia: Related Factors and Consequences on the Quality of Life. Nutrients, 14(18), 1–13. https://doi.org/10.3390/nu14183777
Taufiqurrahman, Hafid, F., Mujayanto, Nuswantari, A., Ratno, Rahayuningtyas, R., Prasetyawan, A. E., & Rahayu, Y. S. (2025). Iron Supplement Adherence, Dietary Intake, and Anemia Risk among Adolescent Girls in Madiun Regency, Indonesia. Journal of Health and Nutrition Research, 4(3). https://doi.org/https://doi.org/10.56303/jhnresearch.v4i3.723
Wardani, D. S. S. J. (2024). Literature Review : Factors Related to Iron Tablets Consumption Compliance among Adolescent Girls in Indonesia. Media Gizi Kesmas, 13(2), 878–897.
Yudina, M. K., & Fayasari, A. (2020). Evaluation of Iron Tablet Supplementation Program of Female Adolescent in East Jakarta. Jurnal Ilmiah Kesehatan (JIKA), 2(3), 147–158. https://doi.org/10.36590/jika.v2i3.56















